EGFR Plasma Testing

Home > Biopsia Liquida  > EGFR Plasma Testing

EGFR Plasma Testing

EGFR blood testing provides NSCLC patients with unavailable or insufficient tumor tissue the opportunity to benefit from personalized treatment.

plasmatesting1

 

Circulating DNA Kit – Cat. No. LCMBL03

  • For isolation of cell-free DNA from serum, plasma and pleural effusion
  • 4 ml sample → 30-100 µl elution
  • High DNA yield and purity
  • Simple procedure (< 90 mins)

 

Cell-free Protection Vacuum Tube – Cat. No. LCMVT01

  • 10 ml blood collection tube for stabilization of cell-free plasma DNA
  • Contains cell-free DNA protection reagent
  • Whole blood collected is stable for 7 days at 4-25°C

 

EGFR 29 Mutation Detection Kit – Cat. No. LCMEG01

  • Detects 29 mutations including T790M in the EGFR gene
  • Detects 1%  mutant allele
  • Positive and negative controls
  • External and internal controls

 

 

EGFR Detection in Blood vs. Matched Tissue

High concordance rate of EGFR detection in blood compared with matched tissue:

 

plasmatesting2

 

EGFR-TKI Efficacy Prediction

EGFR mutation status can predict the efficacy of EGFR-TKIs treatment in advanced NSCLC

Clinical Study FASTACT II

Positive and negative predictive values for EGFR activating mutations were 93% (68/73) and 86% (130/151) respectively.

plasmatesting3

 

EGFR-TKI Drug Resistance Monitoring

EGFR mutation status can monitor the drug resistance of EGFR-TKIs treatment in NSCLC.
T790M ctDNA can be detected in plasma before and after PD and represents a potential poor prognostic factor.

 

plasmatesting4

1) Mok T, et al. 2013 ASCO Abstract 8021
2) D Zheng, et al. 2015 Asco Abstract 8080

Contatto: info@lcm-genect.it

Continua

Questo sito Web utilizza i cookie. Continuando a utilizzare questo sito Web, si presta il proprio consenso all'utilizzo dei cookie. Per maggiori informazioni sulle modalità di utilizzo e di gestione dei cookie, è possibile leggere l'informativa sui cookie.